Program
Keynote lecture 40+10 min
Invited lecture 20+5 min
Selected talk 15+5 min
Registration starting after 4 pm
17:40 Opening by the organizers & Practical
Chair: Vítězslav Bryja
18:00 – 19:00 Keynote lecture I: Hans Clevers “Wnt signaling, Lgr5 stem cells and organoids”
19:00 – 20:30 - 30 second poster presentations
from 20:45 late Welcome reception
Chair: Bon-Kyoung Koo
9:00 – 9:50 Keynote lecture II: Elaine Fuchs "WNT signaling and Stem Cells in the Skin"
9:50 – 10:15 Feng Cong “Control of Wnt receptor turnover and identification of Wnt-dependent tumors”
10:15 – 10:35 Pantelis Hatzis “The role of the long non-coding RNA WiNTRLINC1 in intestinal homeostasis and carcinogenesis”
10:35 – 10:55 Tobias Madl “Molecular Mechanisms of β-catenin - mediated FOXO4 Transcription Factor Activation and Switching"
10:55 – 11:35 Coffee Break
Chair: Madelon Maurice
11:35 – 12:00 Elisabeth Vincan “Fzd7 functions as a stem cell Wnt receptor in the gastrointestinal epithelium”
12:00 – 12:30 Vítězslav Bryja: “Casein kinase 1 epsilon-Dishevelled axis: Mechanisms and treatment opportunities”
12:30 – 12:50 Karl Willert “Regulation of Wnt signaling in human pluripotent stem cells”
13:00 – 14:30 Lunch
Chair: Gunnar Schulte
14:30 – 14:55 Mariann Bienz “Signalosome assembly by Dvl"
14:55 – 15:15 Zachary DeBruine “Structural Insights into Frizzled Receptor Activation by Wnt Ligands”
15:15 – 15:40 Rami Hannoush “Challenges and emerging approaches for targeting protein interfaces in Wnt signaling”
15:40 – 16:00 Sebastian Guettler “Scaffolding functions of Tankyrase in Wnt-β-catenin signaling”
16:00 – 16:50 Coffee Break
Chair: Stephane Angers
16:50 – 17:10 Gunnar Schulte “Novel insights in dynamics of class frizzled receptors”
17:10 – 17:30 Gary Davidson “Novel fluorescence microscopy techniques for the analysis of Wnt ligand-receptor interactions”
17:30 – 17:50 Harald Junge “TSPAN12 Amplifies Frizzled4 Ligand Selectivity and Signaling”
17:50 – 18:10 Hyeyoon Lee “Selective activation of Canonical Wnt signaling over Non-canonical Wnt signaling by Cholesterol binding of Dvl”
18:10 – 21:30 Poster session I - no. 1-75
Beer & wine – finger foods
Chair: Rik Korswagen
9:00 – 9:50 Keynote lecture III: Akira Kikuchi “Epithelial morphogenesis regulated by Wnt signaling and implications in tumorigenesis due to its abnormality”
9:50 – 10:10 Henry Ho “The kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of morphogenetic cell and tissue behaviors”
10:10 –10:30 Bon-Kyoung Koo “Rapid, one-step generation of biallelic conditional gene knockouts”
10:30 – 11:20 Coffee Break
Chair: Vladimír Kořínek
11:20 – 11:45 Konrad Basler “Mechanisms of the Wingless pathway applied to mouse Wnt signaling”
11:45 – 12:05 Babita Madan “Regulation of Wnt signaling by reversible ubiouitylation”
12:05 – 12:25 Julia Christina Gross “Wnt3A induces cancer cell migration via autocrine Wnt5A secretion”
12:25 – 12:45 Ronen Siman-Tov “Wnt Signaling in Red Blood Cells”
13:00 – 14:30 Lunch
Chair: Konrad Basler
14:30 – 14:55 Rik Korswagen "C. elegans neuroblasts switch from non-canonical to canonical Wnt signaling to terminate their migration”
14:55 – 15:15 Anoeska van de Moosdijk “Spatio-temporal quantification of Wnt signalling at physiological levels”
15:15 – 15:40 Christof Niehrs “The Role of Wnt/STOP signaling”
15:40 – 16:00 Nicholas Tolwinski “An optogenetic approach to studying Wnt signaling in living embryos”
16:00 – 16:40 Coffee Break
Chair: Mariann Bienz
16:40 – 17:05 Stefano Piccolo “YAP/TAZ as mediators of Wnt signaling”
17:05 – 17:25 Zachary Steinhart “A CRISPR screen reveals WNT7B-FZD5 signaling as a therapeutic opportunity in pancreatic cancer”
17:25 – 17:45 Madelon Maurice “Alternative polyadenylation of APC mediates formation of a short N-terminal isoform that prevents ß-catenin turnover”
17:45 – 18:05 Steffen Scholpp “Filopodia-based Wnt transport in vertebrates”
18:05 – 21:30 Poster session II - no. 76-150
Conference dinner
Chair: Ernest Arenas
9:00 -9:50 Keynote lecture IV: Marek Mlodzik “WntFrizzled/ Planar Cell Polarity signaling: a macro and microscopic view”
9:50 – 9:15 Patricia Salinas "Deficiency in Wnt signalling triggers synapse degeneration: a role in Alzheimer's Disease"
9:15 – 9:35 Tohru Ishitani “Apoptotic elimination of cells lacking the harmony of Wnt/β-catenin signaling”
10:35 – 11:20 Coffee Break
Chair: Akira Kikuchi
11:20 – 11:40 Alexandra Schambony “The phosphatase PGAM5 antagonizes Wnt/beta-Catenin signaling in embryonic anterior-posterior axis patterning”
11:40 – 12:05 David Virshup “Upstream regulation of Wnt signaling”
12:05 – 12:25 Hidenori Hirai “Crystal structure of human Afamin, a serum glycoprotein that solubilize lipidated Wnt proteins”
12:25 – 12:50 Jean Paul Vincent "Modulation of Wnt signalling by sub cellular trafficking"
13:00 – 14:40 Lunch
Chair: Christof Niehrs
14:40 – 15:05 Marianne Waterman " Wnt and Warburg Metabolism in Stem Cells and Cancer"
15:05 – 15:25 Shinji Takada “Analytical Ultracentrifugation revealed novel Wnt complexes in extracellular space”
15:25 – 15:50 Mayumi Ito “Regulation of Melanocyte stem cells by Wnt signaling”
15:50 – 16:10 Yvonne Jones “Kremen1 Structure and Interactions with LRP6 and Dickkopf”
16:10 – 16:55 Coffee Break
Chair: Vítězslav Bryja
16:55 – 17:20 Ernest Arenas “Improving the dopaminergic differentiation of human pluripotent stem cells using single-cell RNA-sequencing and Wnts”
17:20 – 18:00 scientific closing of the meeting
from 18:00 Wine cellar trip to Prušánky with dinner